Kinda feels like a nothing article. Seems to suggest epigenetic changes without establishing causation or even whether they are are good or bad changes.
This is important because what I've heard (and checked via chatgpt) is that non-smoking consumption of cannabis is protective against certain cancers. Though again many substances (e.g. coffee) are protective against a dozen cancers and but increase risk of a dozen other cancers.
The changes that are common between smoking and cannabis use are presumably related to inhaling smoke?
Your epigenome changes in response to your environment.
Taking antihistamines changes your epigenome.
From the article:
It's important to note that this study doesn't prove that cannabis directly causes these changes or causes health problems.